Depressing hsa_circ_0058092 functions an integrated anti-proliferation and anti-motility role in gastric cancer partially through targeting miR-1294/SIX1 axis

Abstract Fibronectin 1-derived circular RNA hsa_circ_0058092 is a novel potential oncogene in gastric cancer (GC). Yet, previous studies have not determined the role of GC progression and underlying mechanism. Herein, we investigated its competing endogenous (ceRNA) pathway development GC. The results showed that was substantially upregulated patients’ tissues cells, allied with SIX1 downregulated miR-1294 compared normal cells. There were linear correlations among hsa_circ_0058092, levels tumors. Moreover, acted as sponge, targeted SIX1. Functionally, colony formation, EdU positive rate, tumor growth well ki-67 expression xenograft tumors greatly suppressed by depressing hsa_circ_0058092. Besides, knockdown repressed cell migration invasion, accompanied increased E-cadherin descended N-cadherin expression. inhibiting could counteract knockdown-mediated effects inhibitory mimics on malignancy relieved increasing Further, depletion protein interacting miR-1294. Hsa_circ_0058092 oncogenic proliferation motility via ceRNA hsa_circ_0058092/miR-1294/SIX1.